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Phase 2 Interim Data Evaluating The Combination Of Pracinostat And Azacitidine In Patients With Myelodysplastic Syndrome Presented At The 2018 American Society Of Hematology Annual Meeting

LUGANO, Switzerland and San Diego, USA, Dec 4 (Bernama) -- Helsinn Group, a Swiss pharmaceutical group focused on building quality cancer care products, and MEI Pharma, Inc. (Nasdaq: MEIP), an oncology company focused on the clinical development of novel therapies for cancer, today announced interim data from a Phase 2 study evaluating pracinostat, a histone deacetylase inhibitor, in combination with azacitadine for the treatment of patients with IPSS-R high/very high-risk of Myelodysplastic Syndrome (MDS). The data demonstrate a 9% discontinuation rate due to adverse events, a substantially lower rate than observed in an earlier study, as well as an encouraging 36% complete response rate among patients receiving at least 6 cycles of treatment. These data are being presented today at the 2018 American Society of Hematology (ASH) Annual Meeting.

The ongoing Phase 2 open-label study is evaluating a 45 mg dose of pracinostat in combination with azacitadine in order to improve safety/tolerability and retain patients in study longer than in an earlier Phase 2 study evaluating a 60 mg dose. Prolonged treatment is envisaged to result in a systemic exposure to pracinostat sufficient to achieve the desired treatment effect. The data reported today reinforce results from a planned May 2018 interim analysis meeting a predefined discontinuation threshold and suggest a reduced dose of pracinostat may allow MDS patients to remain on treatment longer and thereby increase the likelihood of a treatment response. If the current Phase 2 open-label study is successful, Helsinn intends to initiate a global registration study.


LeddarTech Accelerates Momentum with $US 23.7 Million in Bridge Financing

Latest financing to support LeddarTech’s accelerated growth and development efforts for its proprietary solutions based on its unique automotive LiDAR development platform, which is rapidly gaining traction with Tier-1 suppliers

QUEBEC CITY, Dec 4 (Bernama) -- LeddarTech, an industry leader providing the most versatile and scalable automotive LiDAR development platform, announces the successful closing of a $US 23.7 million ($CDN 31.4 million) bridge. These funds will enable the company to continue the expansion of its research and development teams to accelerate the introduction of its automotive LiDAR development platform.

The financing consists of a revolving loan from Desjardins Group, one of the leading Canadian financial cooperatives, as well as a convertible note from existing shareholders, led by Desjardins-Innovatech, S.E.C.


Kyriba Continues to Expand its #1 Global Solutions Ecosystem with New WorldFirst Partnership

NEW YORK, Dec 4 (Bernama) -- Kyriba, the #1 provider of cloud treasury and financial management solutions, today announced it has expanded its global ecosystem by adding WorldFirst, the foreign exchange and international payments expert, as a new strategic partner to further empower financial executives. Responding to client demand for a better international payments experience and to support a growing trend for global trade, Kyriba’s partnership with WorldFirst will streamline payment processes, increase the speed and transparency of cross-border payments, and also reduce the transfer fees associated with international payments and FX transactions.

According to a recent Kyriba survey[1], the majority of financial executives are unclear about the various fees applied by banks for FX payments. Fifty-four percent of respondents said they are unsure of the spread they are being assessed for their cross-border payments, while 37 percent said they don’t have visibility into what fees they are being charged per payment.


Exim Bank Adopts A Handicapped Elephant As Part Of Its CSR Environmental Initiative

PAHANG, Dec 4 (Bernama) -- EXIM Bank today continues with its CSR commitment in the area of elephant conservation, education and elephants’ welfare at the Kuala Gandah National Elephant Conservation Centre (NECC) by adopting a handicapped baby elephant named Elly.

Last year, EXIM Bank refurbished and redesigned the educational materials for Kuala Gandah NECC as well as funding a custom-made prosthetic leg for a 13 year old female elephant, ‘Selendang’.


Euromonitor International Reveals the World´s Top City Destinations in 2018

LONDON, Dec 4 (Bernama) -- Global market research company Euromonitor International released today the ‘Top 100 City Destinations 2018’ ranking report, covering the world’s leading cities ranked by international tourist arrivals.

The ranking shows that six out of the top 10 most visited cities in 2017 are in Asia, with Hong Kong and Bangkok as the top two performers and with Singapore, Macau, Kuala Lumpur and Shenzhen in the global top 10.


ASEAN Labour Ministers Meeting Adopts Three Vital Documents For The ASEAN Workers - Kula Segaran

KUALA LUMPUR, Dec 4 (Bernama) -- The 25th ASEAN Labour Ministers’ Meeting and its Related Meetings / Conference which concluded on 29 November 2018 have adopted three outcome documents, which were – the ASEAN Declaration on Promoting Green Jobs for Equity and Inclusive Growth of ASEAN Community; Action Plan to implement the ASEAN Consensus on the Protection and Promotion of the Rights of Migrant Workers; and List of ASEAN-OSHNET initiatives to implement the ASEAN Labour Minister’s Statement on improving Occupational Safety and Health for Sustainable Economic Growth.

The theme chosen for this year is Promoting Green Jobs for Equity and Inclusive Growth of ASEAN Community.

Human Resource Minister of Malaysia, M Kula Segaran who chaired the two-day meeting said all three documents were unanimously agreed by all Labour Ministers from all ASEAN member states and its Plus Three Dialogue Partners, namely China, Japan and South Korea.


A Season To Be Jolly With Magical Whimsical Christmas At Suria KLCC

Nutcrackers army guarding the 100 feet Christmas tree at the Esplanade welcoming shoppers to the magical world of “Whimsical Christmas”

KUALA LUMPUR, Dec 4 (Bernama) -- Suria KLCC has transformed into a spectacular whimsical Christmas wonderland. Theme “Whimsical Christmas”, the highlight is a breath-taking poinsettia floral town, decorated with ribbons of colourful lights and snow Christmas tree, festooned with garlands and crystal inspired ornaments. The whimsical wonderland is guarded by colourful Nutcracker army.

“Christmas is one of the most anticipated seasons for Suria KLCC when we bring the magic that comes with the celebration. This year, our magical Christmas town is guarded by the colourful Nutcracker army will make the young smile and bring back the memories of Christmas celebration during your childhood days. It ignites happiness and excitement of this festivity,” said Suria KLCC Chief Executive Officer and Executive Director, Andrew Brien said.